Article: The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM J. Neurosci., 2007
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Other | cultured hippocampus neurons | cell capacitance (pF) | 44.0 ± 3.0 (30) | 44.0 (pF) | Data Table |
Other | cultured hippocampus neurons | input resistance (GΩ) | 0.7 ± 0.1 (30) | 700.0 (MΩ) | Data Table |
Other | cultured hippocampus neurons | resting membrane potential (mV) | -56.0 ± 1.0 (30) | -56.0 (mV) | Data Table |
Other | cultured hippocampus neurons | rheobase (pA) | 38.0 ± 6.0 (30) | 38.0 (pA) | Data Table |
Other | cultured hippocampus neurons | spike amplitude (mV) | 81.0 ± 2.0 (30) | 81.0 (mV) | Data Table |
Other | cultured hippocampus neurons | spike half-width (ms) | 3.7 ± 0.3 (30) | 3.7 (ms) | Data Table |
Other | cultured hippocampus neurons | spike threshold (mV) | -28.0 ± 0.9 (30) | -28.0 (mV) | Data Table |
Metadata values
Experimental condition | Value |
---|---|
Species | Rats |
ElectrodeType | Patch-clamp |
PrepType | in vitro |
PrepType | cell culture |
RecTemp | 20.0 - 22.0 |
ExternalSolution | 5.0 |
InternalSolution | 5.0 |
JxnPotential | Unreported |
AnimalAge | 18.0 |
internal_0_pH | 7.3 |
internal_0_Na | 10.0 |
internal_0_EGTA | 1.0 |
internal_0_HEPES | 10.0 |
internal_0_Cl | 10.0 |
internal_0_Cs | 140.0 |
external_0_pH | 7.3 |
external_0_Mg | 1.0 |
external_0_Na | 140.0 |
external_0_K | 3.0 |
external_0_HEPES | 20.0 |
external_0_Cl | 147.0 |
external_0_Ca | 1.0 |
external_0_CNQX | 6.0 |
external_0_BIC | 10.0 |
external_0_DAPV | 100.0 |
Data table listing
Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
---|---|---|---|---|---|---|---|---|
2134 | The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. | Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM | J. Neurosci. | 2007 | False | 7 | Shreejoy Tripathy, Ryan Sefidpour, | 3 |
2133 | The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. | Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM | J. Neurosci. | 2007 | False | 0 | None |